![]() Next, the weight, symptom score, morphological changes, viral load, membrane fusion proteins, critical proteins of the Toll-like receptor signaling pathway, cytokines, and immune cells of vaginal tissue in mice at different time points were measured. First, we optimized a mouse model of genital herpes. The fingerprint of JieZe-1 was determined by high-performance liquid chromatography. ![]() This study was designed to evaluate the anti-HSV-2 effect of JieZe-1 and berberine in a genital herpes mouse model and explore the underlying mechanism. ![]() However, its mechanism of anti-HSV-2 effect in vivo remains unclear. It showed an excellent anti-HSV-2 effect in vitro. 3Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaĬhinese herbal prescription JieZe-1 is effective for genital herpes with no visible adverse effects clinically.2Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.1Department of TCM, Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Qianni Duan 1 † Tong Liu 1 † Cong Huang 1 Qingqing Shao 1 Yonggui Ma 2 Wenjia Wang 1 Tianli Liu 1 Jun Sun 3 Jianguo Fang 2 Guangying Huang 1 Zhuo Chen 1*
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